Single-neuron observations mark steps in Alzheimer's disease
Multiple disease-related changes progress in parallel through distinct stages
Studying a mouse model of Alzheimer's disease, a team led by TUM-IAS Carl von Linde Senior Fellow Prof. Arthur Konnerth, has observed correlations between increases in both soluble and plaque-forming beta-amyloid – a protein implicated in the disease process – and dysfunctional developments on several levels: individual cortical neurons, neuronal circuits, sensory cognition, and behavior. Their results, published in Nature Communications, show that these changes progress in parallel and that, together, they reveal distinct stages in Alzheimer's disease with a specific order in time.
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