Prenatal exposure to maternal psychosocial stress confers a lifelong risk for behavioral alterations that last beyond childhood. Our aim is to identify non-invasive biomarkers of the childdevelopmental outcome to offer a precise and truly personalized prediction and new possibilities for designing interventions to improve neurodevelopmental outcomes of pregnancy affected by prenatal stress. full report …
Short CV
Marta C. Antonelli received her Biochemist and PhD degree in Neurochemistry from the University of Buenos Aires, Argentina. Upon receiving her PhD degree, she moved to Seattle, WA, USA for a postdoctoral stay at the Veterans Administration Medical Center/University of Washington. Back in Buenos Aires, she is currently head of the Laboratory of Perinatal Programming of Neurodevelopment at the Faculty of Medicine, University of Buenos Aires and holds a position as Principal Researcher of the CONICET (National Research Council). Since 2021, she has been President of the Executive Council of the Argentine Society for Neuroscience (SAN). The focus of her research is centered in the study of the offspring outcome in a rodent model of prenatal restraint stress. For two consecutive periods, she was recipient of the August-Wilhelm Scheer Visiting Professorship Program (Technische Universität München) to develop a translational project at the Frauenklinik und Poliklinik, Klinikum rechts der Isar, Munich, Germany, to investigate the long term effect of prenatal stress on children outcome and identify potential biomarkers to orient early interventional programs in humans.
Selected Awards
2016, August-Wilhelm Scheer Visiting Professorship Program (TUM)
2009, President of the International Society for Neurotoxicity
1987, Postdoctoral Fellowship (International), CONICET. Argentina
1984, Postdoctoral Fellowship (National), CONICET. Argentina
1979, Doctoral Fellowship. CONICET. Argentina
Research Interests
Prenatal stress, dopamine, glutamate, corticolimbic system, rats, crossfostering, cortisol, HPA axis, autonomic nervous system, biomarkers, neurodevelopment, epigenetics, DNA methylation, plasticity, substance use disorders, early stimulation.
Selected Publications
“Unravelling the Link Between Prenatal Stress, Dopamine and Substance Use Disorder”. V. Pastor , MC. Antonelli, ME. Pallares. Neurotox Res.31(1):169-186. 2017.(doi: 10.1007/s12640-016-9674-9)
¨Long-Term consequences of prenatal insults on neurodevelopment¨. MC. Antonelli, ME. Pallarés, S. Ceccatelli, S. Spulber. Progress in Neurobiology. 155: 21–35. 2017. (doi: 10.1016/j.pneurobio.2016.05.005).
“Prenatal stress increases adult vulnerability to cocaine reward without affecting pubertal anxiety or novelty response”. V. Pastor, ME. Pallarés, MC. Antonelli. Behav Brain Res. 339:186-194. 2018. (doi: 10.1016/j.bbr.2017.11.035).
“In Vivo and in Vitro Neuronal Plasticity Modulation by Epigenetic Regulators”. MC. Monteleone, ME. Pallarés, SC. Billi, MC. Antonelli, MA. Brocco. J.Mol. Neurosci. 2018. 65(3):301-311. (doi: 10.1007/s12031-018-1101-7).
“Microglial memory of early life stress and inflammation: susceptibility to neurodegeneration in adulthood”. P. Desplats, AM. Gutierrez, MC. Antonelli, MG. Frasch. Neuroscience & Biobehavioral Reviews. 2020. 117:232-242. doi.org/10.1016/j.neubiorev. 2019.10.013.
“Prefrontal cortex alpha 7 nicotinic receptors are necessary for cocaine-associated memory acquisition and retrieval”. V. Pastor; F. Castillo Díaz; VC. Sanabria; JF. Dalto; MC. Antonelli; JH. Medina. Behavioural Brain Research. 2021. doi: 10.1016/j.bbr.2021.113212.
Antonelli, Marta C.; Frasch, Martin G.; Rumi, Mercedes; Sharma, Ritika; Zimmermann, Peter; Molinet, Maria S.; Lobmaier, Silvia M.: Early Biomarkers and Intervention Programs for the Infant Exposed to Prenatal Stress. Current Neuropharmacology 20 (1), 2022, 94-106 mehr…BibTeX
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Sharma, Ritika; Frasch, Martin G.; Zelgert, Camila; Zimmermann, Peter; Fabre, Bibiana; Wilson, Rory; Waldenberger, Melanie; MacDonald, James W.; Bammler, Theo K.; Lobmaier, Silvia M.; Antonelli, Marta C.: Maternal–fetal stress and DNA methylation signatures in neonatal saliva: an epigenome-wide association study. Clinical Epigenetics 14 (1), 2022 mehr…BibTeX
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Zimmermann, Peter; Antonelli, Marta C.; Sharma, Ritika; Müller, Alexander; Zelgert, Camilla; Fabre, Bibiana; Wenzel, Natasha; Wu, Hau-Tieng; Frasch, Martin G.; Lobmaier, Silvia M.: Prenatal stress perturbs fetal iron homeostasis in a sex specific manner. Scientific Reports 12 (1), 2022 mehr…BibTeX
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2021
Antonelli, Marta C.; Frasch, Martin G.; Rumi, Mercedes; Sharma, Ritika; Zimmermann, Peter; Molinet, Maria Sol; Lobmaier, Silvia M.: Early Biomarkers and Intervention Programs for the Infant Exposed to Prenatal Stress. Current Neuropharmacology 19, 2021 mehr…BibTeX
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Cerritelli, Francesco; Frasch, Martin G.; Antonelli, Marta C.; Viglione, Chiara; Vecchi, Stefano; Chiera, Marco; Manzotti, Andrea: A Review on the Vagus Nerve and Autonomic Nervous System During Fetal Development: Searching for Critical Windows. Frontiers in Neuroscience 15, 2021 mehr…BibTeX
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Sarkar, Pritam; Lobmaier, Silvia; Fabre, Bibiana; González, Diego; Mueller, Alexander; Frasch, Martin G.; Antonelli, Marta C.; Etemad, Ali: Detection of Maternal and Fetal Stress from the Electrocardiogram with Self-Supervised Representation Learning. 2021 mehr…BibTeX
Sarkar, Pritam; Lobmaier, Silvia; Fabre, Bibiana; González, Diego; Mueller, Alexander; Frasch, Martin G.; Antonelli, Marta C.; Etemad, Ali: Detection of maternal and fetal stress from the electrocardiogram with self-supervised representation learning. Scientific Reports 11 (1), 2021 mehr…BibTeX
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2019
Lobmaier, Silvia M.; Müller, A.; Zelgert, C.; Shen, C.; Su, P. C.; Schmidt, G.; Haller, B.; Berg, G.; Fabre, B.; Weyrich, J.; Wu, H. T.; Frasch, M. G.; Antonelli, M. C.: Fetal heart rate variability responsiveness to maternal stress, non-invasively detected from maternal transabdominal ECG. Archives of Gynecology and Obstetrics 301 (2), 2019, 405-414 mehr…BibTeX
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Lobmaier, Silvia M.; Müller, A.; Zelgert, C.; Shen, C.; Su, P. C.; Schmidt, G.; Haller, B.; Berg, G.; Fabre, B.; Weyrich, J.; Wu, H. T.; Frasch, M. G.; Antonelli, M. C.: Fetal heart rate variability responsiveness to maternal stress, non-invasively detected from maternal transabdominal ECG. Archives of Gynecology and Obstetrics, 2019 mehr…BibTeX
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