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Stanley Riddell

Stanley Riddell

Fellowship

Hans Fischer Senior Fellow
Stanley Riddell received his M.D. from the University of Manitoba in Winnipeg, Canada. He trained in Medical Oncology and Immunology at the Fred Hutchinson Cancer Research Center and the University of Washington from 1985 – 1990. He subsequently joined the faculty at these institutions, and is currently Member and Associate Program Head of the Program in Immunology at the Fred Hutchinson Cancer Research Center and Professor, Department of Medicine at the University of Washington.
1992-1996 Cancer Research Institute Partridge Foundation Investigator Award

2000 Japan Health Sciences Foundation Fellowship Visiting Scientist

2002 Woodward Visiting Professor, Memorial Sloan Kettering Cancer Center

2003 Gerhardt Schmidt Memorial Lecture, City of Hope National Medical Center

2004 Gerald Goldenberg Lecture, University of Toronto, Toronto, Canada

2008 Elected Fellow of the American College of Physicians
M. Nauerth, B. Weißbrich, R. Knall, T. Franz, G. Dössinger, J. Bet, P. J. Paszkiewicz, L. Pfeifer, M. Bunse, W. Uckert, R. Holtappels, D. Gillert-Marien, M. Neuenhahn, A. Krackhardt, M. J. Reddehase, S. R. Riddell, and D. H. Busch, “TCR-ligand koff rate correlates with the protective capacity of antigen-specific CD8+ T cells for adoptive transfer,” Sci. Transl. Med., vol. 5, no. 192, pp. 192ra87, 2013.

V. R. Buchholz, M. Flossdorf, I. Hensel, L. Kretschmer, B. Weissbrich, P. Gräf, A. Verschoor, M. Schiemann, T. Höfer, and D. H. Busch, “Disparate individual fates compose robust CD8+ T cell im-munity,” Science, vol. 340, no. 6132, pp. 630 – 635, 2013.

C. Stemberger, S. Dreher, C. Tschulik, C. Piossek, J. Bet, T.N. Yamamoto, M. Schiemann, M. Neuenhahn, K. Martin, M. Schlapschy, A. Skerra, T. Schmidt, M. Edinger, S.T. Riddell, Germeroth L, and D.H. Busch, "Novel serial positive enrich-ment technology enables clinical multiparameter cell sorting," PloS One, vol.7, no. 4, e35798, 2012.

S. Terakura, T.N. Yamamoto, R.A. Gardner, C.J. Turtle, M.C. Jensen, S.R. Riddell, "Generation of CD19-chimeric antigen receptor modified CD8+T cells derived from virus-specific central memory T cells," Blood, vol. 119, no. 1, pp. 72 – 82, 2012.

C.J. Turtle, Swanson H.M., Fujii N., Estey E.H., S.R. Riddell, "A distinct subset of self-renewing human memory CD8+ T cells survives cytotoxic chemotherapy," Immunity.

C. Berger, C.J. Turtle, M.C. Jensen, S.R. Riddell, "Adoptive transfer of virus-specific and tumor-specific T cells," Current Opinion in Immunology, vol. 21, pp. 224-232, 2009.

C. Berger, Jensen M.J., P. Lansdorp, S.R. Riddell, "Adoptive transfer of T cell clones derived from central memory T cells establishes persistent and functional T cell memory," Journal of Clinical Investigation, vol. 118, pp. 294-305, 2008.

E.H. Warren, N.H. Vigneron, P. Coulie, M.A. Gavin, V. Stroobant, J. Chapiro, A. Dalet, S.S. Tykodi, S.M. Xuereb, J. Mito, S.R. Riddell, B.J. Van den Eynde, "A minor histocompatibility antigen produced in the proteasome by splicing of non-contiguous peptide fragments in the reverse order," Science, vol. 313 pp. 1444-1447, 2006.

Bleakely M., S.R. Riddell, "Molecules and mechanisms of the graft versus leukemia effect," Nature Reviews Cancer, vol. 4, pp. 371-380, 2004.

C. Yee, J.A. Thompson, P. Roche, D.R. Byrd, P.P. Lee, M. Piepkorn, K. Kenyon, M.M. Davis, S.R. Riddell and P.D. Greenberg., "Melanocyte destruction after antigen-specific immunotherapy of melanoma: direct evidence of T cell-mediated vitiligo," Journal of Experimental Medicine, vol. 192, pp. 1637-1634, 2000.

D. Bonnet, E.H. Warren, P.D. Greenberg, J. Dick, S.R. Riddell, "CD8+ minor histocompatibility antigen-specific cytotoxic T lymphocyte clones eliminate AML stem cells," Proceedings of the National Academy of Sciences, vol. 96, pp. 8639-8644, 1999.

P.D. Greenberg, S.R. Riddell, "Cellular Immunodeficiencies: Finding and fixing the defects," Science, vol. 285, pp. 546-551,1999.

Walter E.A., P.D. Greenberg, M.J. Gilbert, R.J. Finch, K.S. Watanabe, E.D. Thomas, and S.R. Riddell, "Reconstitution of CMV immunity in bone marrow transplant recipients by adoptive immunotherapy with CD8+ T cell clones," N. Engl. J. Med., vol. 333, pp. 1038-1044, 1995.

S.R. Riddell, K.S. Watanabe, J.M. Goodrich, C.R. Li, M.E. Agha and P.D. Greenberg, "Restoration of viral immunity in immunocompromised humans by adoptive transfer of T cell clones," Science, vol. 257, pp. 238-241, 1992.





The Riddell lab has focused on the development and clinical evaluation of cellular therapeutics with antigen-specific T cell lymphocytes for human viral infections and malignancy. The research effort in this area encompasses the identification of appropriate target antigens on infected and malignant cells, and the development of methods for selecting and expanding therapeutic T cells of the correct specificity. Recent studies have been directed at understanding the genetic programming of distinct memory T cell subsets that enable some cells to survive long-term in vivo and to reestablish immunologic memory after adoptive transfer.



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