Dr. Marco Punta worked as a Carl von Linde Junior Fellow at TUM-IAS. With the Burkhard Rost Group he studied how protein sequence is modified by evolutionary processes under structural and functional constraints. On the one hand, he tried to detect evolutionary signals in sequences and structures that may help to better characterize individual protein families. On the other, he intended to develop new methods and strategies to study remote relationships between families, using structural information as a key. Applications include proteins function annotation and protein design.