Technische Universität München

Silvio Aime graduated from the University of Turin in 1971. After a stint at the University of East Anglia, he returned to Turin in 1974 where he spent his entire career. He is currently Professor of General and Inorganic Chemistry (Faculty of Sciences, degree course in Biotechnologies), and the head of the NMR laboratory of the Department of Chemistry, and the Center for Molecular Imaging at the University of Torino. Professor Aime’s main research is focused on developing diagnostic agents containing lanthanides or hyperpolarized molecules for applications of magnetic resonance imaging with a particular interest in molecular imaging procedures.

2011 Honorary Doctorate from the Technology University Eindhoven

2010 Doctor honoris causa from the University of Debrecen

2010 Award from the European Soc. Magnetic Resonance in Medicine and Biology

2004 European Magnetic Resonance Foundation Award

2000 Sapio Prize

1996 Medal from the Italian NMR Discussion Group

1987 Nasini Medal from the Italian Chemical Society

1) Castelli, DD; Dastru, W; Terreno, E; Cittadino, E; Mainini, F; Torres, E; Spadaro, M; Aime, S, In vivo MRI multicontrast kinetic analysis of the uptake and intracellular trafficking of paramagnetically labeled liposomes, JOURNAL OF CONTROLLED RELEASE 144 (3):271-279 2010

2) Digilio, G; Menchise, V; Gianolio, E; Catanzaro, V; Carrera, C; Napolitano, R; Fedeli, F; Aime, S, Exofacial Protein Thiols as a Route for the Internalization of Gd(III)-Based Complexes for Magnetic Resonance Imaging Cell Labeling, JOURNAL OF MEDICINAL CHEMISTRY 53 (13):4877-4890 2010

3) Tei, L; Barge, A; Crich, SG; Pagliarin, R; Negri, V; Ramella, D; Cravotto, G; Aime, S, Target Visualization by MRI Using the Avidin/Biotin Amplification Route: Synthesis and Testing of a Biotin-Gd-DOTA Monoamide Trimer, CHEMISTRY-A EUROPEAN JOURNAL 16 (27):8080-8087 2010

4) Tei, L; Mazooz, G; Shellef, Y; Avni, R; Vandoorne, K; Barge, A; Kalchenko, V; Dewhirst, MW; Chaabane, L; Miragoli, L; Longo, D; Neeman, M; Aime, S, Novel MRI and fluorescent probes responsive to the Factor XIII transglutaminase activity, CONTRAST MEDIA & MOLECULAR IMAGING 5 (4):213-222 2010

5) Kalman, FK; Geninatti-Crich, S; Aime, S, Reduction/Dissolution of a beta-MnOOH Nanophase in the Ferritin Cavity To Yield a Highly Sensitive, Biologically Compatible Magnetic Resonance Imaging Agent, ANGEWANDTE CHEMIE-INTERNATIONAL EDITION 49 (3):612-615 2010

6) Viale, A; Aime, S, Current concepts on hyperpolarized molecules in MRI, CURRENT OPINION IN CHEMICAL BIOLOGY 14 (1):90-96 2010

7) Grange, C; Geninatti-Crich, S; Esposito, G; Alberti, D; Tei, L; Bussolati, B; Aime, S; Camussi, G, Combined Delivery and Magnetic Resonance Imaging of Neural Cell Adhesion Molecule-Targeted Doxorubicin-Containing Liposomes in Experimentally Induced Kaposi's Sarcoma, CANCER RESEARCH 70 (6):2180-2190 2010

8) Terreno, E; Castelli, DD; Viale, A; Aime, S, Challenges for Molecular Magnetic Resonance Imaging, CHEMICAL REVIEWS 110 (5):3019-3042 2010

9) Aime, S; Delli Castelli, D; Geninatti Crich, S; Gianolio, E; Terreno, E, Pushing the Sensitivity Envelope of Lanthanide-Based Magnetic Resonance Imaging (MRI) Contrast Agents for Molecular Imaging Applications, ACCOUNTS OF CHEMICAL RESEARCH 42 (7):822-831 2009

10) Stefania, R (Stefania, Rachele); Tei, L (Tei, Lorenzo); Barge, A (Barge, Alessandro); Crich, SG (Crich, Simonetta Geninatti); Szabo, I (Szabo, Ibolya); Cabella, C (Cabella, Claudia); Cravotto, G (Cravotto, Giancarlo); Aime, S (Aime, Silvio), Tuning Glutamine Binding Modes in Gd-DOTA-Based Probes for an Improved MRI Visualization of Tumor Cells, CHEMISTRY-A EUROPEAN JOURNAL, 15 (1): 76-85 2009