Current Fellows
Christian Stemberger
Germany2010
Fellowship
Carl von Linde Junior Fellow
Carl von Linde Junior Fellow
Institution
Technische Universität München
Technische Universität München
Host
Dirk H. Busch
Dirk H. Busch
Short CV
Christian Stemberger studied Biology and received his Diploma (in Molecular Biology and Biochemistry) in 2004 from TUM. From 2004 to 2008 he performed his PhD thesis work in immunology at TUM (dissertation: Origin of CD8+T cell subsets; Thesis Advisor Prof. Dirk Busch). After finishing his thesis he continued working as a postdoctorate at the Institute for Medical Microbiology, Immunology and Hygiene.
Selected Publications
Stemberger, C., Huster, K.M., Koffler, M., Anderl, F., Schiemann, M., Wagner, H., and Busch, D.H. (2007). A Single Naive CD8(+) T Cell Precursor Can Develop into Diverse Effector and Memory Subsets. Immunity 27, 985-997.
Stemberger, C., Neuenhahn, M., Gebhardt, F.E., Schiemann, M., Buchholz, V.R., and Busch, D.H. (2009). Stem cell-like plasticity of naive and distinct memory CD8+ T cell subsets. Semin Immunol 21, 62-68
Stemberger, C., Neuenhahn, M., Buchholz, V.R., and Busch, D.H. (2007). Origin of CD8+ Effector and Memory T Cell Subsets. Cell Mol Immunol 4, 399-405.
Stemberger, C., Huster, K.M., and Busch, D.H. (2006). Defining correlates of T cell protection against infection. Discov Med 6, 148-152.
Huster, K.M., Koffler, M., Stemberger, C., Schiemann, M., Wagner, H., and Busch, D.H. (2006). Unidirectional development of CD8+ central memory T cells into protective Listeria-specific effector memory T cells. Eur J Immunol 36, 1453-1464.
Kriegeskorte, A.K., Gebhardt, F.E., Porcellini, S., Schiemann, M., Stemberger, C., Franz, T.J., Huster, K.M., Carayannopoulos, L.N., Yokoyama, W.M., Colonna, M., et al. (2005). NKG2D-independent suppression of T cell proliferation by H60 and MICA. Proc Natl Acad Sci U S A 102, 11805-11810.
Neuenhahn, M., Kerksiek, K.M., Nauerth, M., Suhre, M.H., Schiemann, M., Gebhardt, F.E., Stemberger, C., Panthel, K., Schroder, S., Chakraborty, T., et al. (2006). CD8alpha+ dendritic cells are required for efficient entry of Listeria monocytogenes into the spleen. Immunity 25, 619-630.
Huster, K.M., Stemberger, C., Gasteiger, G., Kastenmüller, W., Drexler, I. and Busch, D.H. (2009). Memory CD8 T cell compartment grows in size but nevertheless can loose function. J Immunol, in press
Stemberger, C., Neuenhahn, M., Gebhardt, F.E., Schiemann, M., Buchholz, V.R., and Busch, D.H. (2009). Stem cell-like plasticity of naive and distinct memory CD8+ T cell subsets. Semin Immunol 21, 62-68
Stemberger, C., Neuenhahn, M., Buchholz, V.R., and Busch, D.H. (2007). Origin of CD8+ Effector and Memory T Cell Subsets. Cell Mol Immunol 4, 399-405.
Stemberger, C., Huster, K.M., and Busch, D.H. (2006). Defining correlates of T cell protection against infection. Discov Med 6, 148-152.
Huster, K.M., Koffler, M., Stemberger, C., Schiemann, M., Wagner, H., and Busch, D.H. (2006). Unidirectional development of CD8+ central memory T cells into protective Listeria-specific effector memory T cells. Eur J Immunol 36, 1453-1464.
Kriegeskorte, A.K., Gebhardt, F.E., Porcellini, S., Schiemann, M., Stemberger, C., Franz, T.J., Huster, K.M., Carayannopoulos, L.N., Yokoyama, W.M., Colonna, M., et al. (2005). NKG2D-independent suppression of T cell proliferation by H60 and MICA. Proc Natl Acad Sci U S A 102, 11805-11810.
Neuenhahn, M., Kerksiek, K.M., Nauerth, M., Suhre, M.H., Schiemann, M., Gebhardt, F.E., Stemberger, C., Panthel, K., Schroder, S., Chakraborty, T., et al. (2006). CD8alpha+ dendritic cells are required for efficient entry of Listeria monocytogenes into the spleen. Immunity 25, 619-630.
Huster, K.M., Stemberger, C., Gasteiger, G., Kastenmüller, W., Drexler, I. and Busch, D.H. (2009). Memory CD8 T cell compartment grows in size but nevertheless can loose function. J Immunol, in press
Research Interests
Christian Stemberger´s research interests focus on the development of cellular therapeutics for infections as well as certain forms of cancer and other immunologically related diseases. His special interest lies in the generation of molecular methods that allow for highly specific and reversible selection, as well as purification of immunologically relevant cells such as antigen-specific CD8+ T cells, NK cells and/or regulatory T cells. Together with the development of technically advanced selection and processing techniques (like magnetic cell sorting and flow cytometry) GMP-grade cellular products should be generated for future clinical applications. Further studies involve the understanding of the generation of robust and long-lasting T cell responses in vivo and their implication for adoptive T cell therapy.
